They conclude that hydroxocobalamin meets both of these criteria.
They state that empiric treatment, which would be the automatic administration of a given therapy when the condition is suspected, should be both safe and effective. The authors review the current literature supporting the use of these agents as well as the current research that indicates the need for increased awareness of cyanide poisoning in combination with smoke inhalation. This comprehensive review by the authors examines the pros and cons of two cyanide antidote treatments sodium thiosulfate, which is a component of the commonly referred to Pasadena or Lilly kit, and hydroxocobalamin, which is a precursor of vitamin B12 and has been in use for years in many countries and exclusively in Europe. Review of: Hall A, Dart R, Bogdan G: Sodium thiosulfate or hydroxocobalamin for the empiric treatment of cyanide poisoning? Annals of Emergency Medicine.
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